1,115 research outputs found
Use of apomorphine in Parkinsonian patients with neuropsychiatric complications to oral treatment
Neuropsychiatric side effects often complicate anti-Parkinsonian therapy and pose a significant problem in the optimal management of idiopathic Parkinson's disease. Several publications report a relative lack of neuropsychiatric side effects in Parkinsonian patients treated with subcutaneous apomorphine. To investigate this further, we have used subcutaneous apomorphine to treat 12 non-demented IPD patients with previous oral drug-related neuropsychiatric problems. Treatment with apomorphine allowed alteration of anti-Parkinsonian medication and led to the abolition or reduction of neuropsychiatric complications in all patients. The mechanism remains unclear but may be due, in part, to a reduction in oral medication or a psychotropic action of apomorphine, possibly due to the piperidine moiety in its structure, or both
Functional specialization within rostral prefrontal cortex (Area 10): a meta-analysis
One of the least well understood regions of the human brain is rostral prefrontal cortex, approximating Brodmann's area 10. Here, we investigate the possibility that there are functional subdivisions within this region by conducting a meta-analysis of 104 functional neuroimaging studies (using positron emission tomography/functional magnetic resonance imaging). Studies involving working memory and episodic memory retrieval were disproportionately associated with lateral activations, whereas studies involving mentalizing (i.e., attending to one's own emotions and mental states or those of other agents) were disproportionately associated with medial activations. Functional variation was also observed along a rostral-caudal axis, with studies involving mentalizing yielding relatively caudal activations and studies involving multiple-task coordination yielding relatively rostral activations. A classification algorithm was trained to predict the task, given the coordinates of each activation peak. Performance was well above chance levels (74% for the three most common tasks; 45% across all eight tasks investigated) and generalized to data not included in the training set. These results point to considerable functional segregation within rostral prefrontal cortex
Evolution models for mass transportation problems
We present a survey on several mass transportation problems, in which a given
mass dynamically moves from an initial configuration to a final one. The
approach we consider is the one introduced by Benamou and Brenier in [5], where
a suitable cost functional , depending on the density and on
the velocity (which fulfill the continuity equation), has to be minimized.
Acting on the functional various forms of mass transportation problems can
be modeled, as for instance those presenting congestion effects, occurring in
traffic simulations and in crowd motions, or concentration effects, which give
rise to branched structures.Comment: 16 pages, 14 figures; Milan J. Math., (2012
Structural transitions in granular packs: statistical mechanics and statistical geometry investigations
We investigate equal spheres packings generated from several experiments and
from a large number of different numerical simulations. The structural
organization of these disordered packings is studied in terms of the network of
common neighbours. This geometrical analysis reveals sharp changes in the
network's clustering occurring at the packing fractions (fraction of volume
occupied by the spheres respect to the total volume, ) corresponding to
the so called Random Loose Packing limit (RLP, ) and Random
Close Packing limit (RCP, ). At these packing fractions we
also observe abrupt changes in the fluctuations of the portion of free volume
around each sphere. We analyze such fluctuations by means of a statistical
mechanics approach and we show that these anomalies are associated to sharp
variations in a generalized thermodynamical variable which is the analogous for
these a-thermal systems to the specific heat in thermal systems.Comment: 7 pages, 6 figure
Multifractal stationary random measures and multifractal random walks with log-infinitely divisible scaling laws
We define a large class of continuous time multifractal random measures and
processes with arbitrary log-infinitely divisible exact or asymptotic scaling
law. These processes generalize within a unified framework both the recently
defined log-normal Multifractal Random Walk (MRW) [Bacry-Delour-Muzy] and the
log-Poisson "product of cynlindrical pulses" [Barral-Mandelbrot]. Our
construction is based on some ``continuous stochastic multiplication'' from
coarse to fine scales that can be seen as a continuous interpolation of
discrete multiplicative cascades. We prove the stochastic convergence of the
defined processes and study their main statistical properties. The question of
genericity (universality) of limit multifractal processes is addressed within
this new framework. We finally provide some methods for numerical simulations
and discuss some specific examples.Comment: 24 pages, 4 figure
Standard Model baryogenesis through four-fermion operators in braneworlds
We study a new baryogenesis scenario in a class of braneworld models with low
fundamental scale, which typically have difficulty with baryogenesis. The
scenario is characterized by its minimal nature: the field content is that of
the Standard Model and all interactions consistent with the gauge symmetry are
admitted. Baryon number is violated via a dimension-6 proton decay operator,
suppressed today by the mechanism of quark-lepton separation in extra
dimensions; we assume that this operator was unsuppressed in the early Universe
due to a time-dependent quark-lepton separation. The source of CP violation is
the CKM matrix, in combination with the dimension-6 operators. We find that
almost independently of cosmology, sufficient baryogenesis is nearly impossible
in such a scenario if the fundamental scale is above 100 TeV, as required by an
unsuppressed neutron-antineutron oscillation operator. The only exception
producing sufficient baryon asymmetry is a scenario involving
out-of-equilibrium c quarks interacting with equilibrium b quarks.Comment: 39 pages, 5 figures v2: typos, presentational changes, references and
acknowledgments adde
Safety and Immunogenicity of a Recombinant Adenovirus Serotype 35-Vectored HIV-1 Vaccine in Adenovirus Serotype 5 Seronegative and Seropositive Individuals.
BACKGROUND: Recombinant adenovirus serotype 5 (rAd5)-vectored HIV-1 vaccines have not prevented HIV-1 infection or disease and pre-existing Ad5 neutralizing antibodies may limit the clinical utility of Ad5 vectors globally. Using a rare Ad serotype vector, such as Ad35, may circumvent these issues, but there are few data on the safety and immunogenicity of rAd35 directly compared to rAd5 following human vaccination.
METHODS: HVTN 077 randomized 192 healthy, HIV-uninfected participants into one of four HIV-1 vaccine/placebo groups: rAd35/rAd5, DNA/rAd5, and DNA/rAd35 in Ad5-seronegative persons; and DNA/rAd35 in Ad5-seropositive persons. All vaccines encoded the HIV-1 EnvA antigen. Antibody and T-cell responses were measured 4 weeks post boost immunization.
RESULTS: All vaccines were generally well tolerated and similarly immunogenic. As compared to rAd5, rAd35 was equally potent in boosting HIV-1-specific humoral and cellular immunity and responses were not significantly attenuated in those with baseline Ad5 seropositivity. Like DNA, rAd35 efficiently primed rAd5 boosting. All vaccine regimens tested elicited cross-clade antibody responses, including Env V1/V2-specific IgG responses.
CONCLUSIONS: Vaccine antigen delivery by rAd35 is well-tolerated and immunogenic as a prime to rAd5 immunization and as a boost to prior DNA immunization with the homologous insert. Further development of rAd35-vectored prime-boost vaccine regimens is warranted
Dynamical stability of infinite homogeneous self-gravitating systems: application of the Nyquist method
We complete classical investigations concerning the dynamical stability of an
infinite homogeneous gaseous medium described by the Euler-Poisson system or an
infinite homogeneous stellar system described by the Vlasov-Poisson system
(Jeans problem). To determine the stability of an infinite homogeneous stellar
system with respect to a perturbation of wavenumber k, we apply the Nyquist
method. We first consider the case of single-humped distributions and show
that, for infinite homogeneous systems, the onset of instability is the same in
a stellar system and in the corresponding barotropic gas, contrary to the case
of inhomogeneous systems. We show that this result is true for any symmetric
single-humped velocity distribution, not only for the Maxwellian. If we
specialize on isothermal and polytropic distributions, analytical expressions
for the growth rate, damping rate and pulsation period of the perturbation can
be given. Then, we consider the Vlasov stability of symmetric and asymmetric
double-humped distributions (two-stream stellar systems) and determine the
stability diagrams depending on the degree of asymmetry. We compare these
results with the Euler stability of two self-gravitating gaseous streams.
Finally, we determine the corresponding stability diagrams in the case of
plasmas and compare the results with self-gravitating systems
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